研究兴趣与方向:
病原微生物与宿主互作的分子机制研究
生殖发育过程中关键大分子的结构与功能研究
代表性论文: (*Corresponding authors; #Co-first authors)
1. Weiwei Ji#, Qi Peng#, Xueqiong Fang, Zehou Li, Yaxin Li, Cunfa Xu, Shuqing Zhao, Jizong Li, Rong Chen, Guoxiang Mo, Zhanyong Wei, Ying Xu*, Bin Li*, Shuijun Zhang*. Structures of a deltacoronavirus spike protein bound to porcine and human receptors. Nat. Commun. 2022, 13: 1467
2. Xu X#, Peng R#, Peng Q#, Wang M, Xu Y, Liu S, Tian X, Deng H, Tong Y, Hu X, Zhong J, Wang P, Qi J, Gao GF, Shi Y*. （2021）Cryo-EM structures of Lassa and Machupo virus polymerases complexed with cognate regulatory Z proteins identify targets for antivirals. Nat Microbiol. 2021 Jul;6(7):921-931. doi: 10.1038/s41564-021-00916-w. Epub 2021 Jun 14. PMID: 34127846.
3. Xu Y, Peng R, Zhang W, Qi J, Song H, Liu S, Wang H, Wang M, Xiao H, Fu L, Fan Z, Bi Y, Yan J, Shi Y and George F. Gao*. (2019) Avian-to-human Receptor Binding Adaptation of Avian H7N9 Influenza Virus Hemagglutinin. Cell Rep., 29, 2217-2228.
4. Peng R#, Li Z#, Xu Y#, He S, Peng Q, Wu L, Qi J, Wang P, Shi Y and George F. Gao*. (2019) Structural insight into multistage inhibition of CRISPR-Cas12a by AcrVA4. Proc. Natl. Acad. Sci. USA, 116, 18928-18936.
5. Peng R#, Xu Y#, Zhu T#, Li N#, Qi J, Chai Y, Wu M, Zhang X, Shi Y, Wang P, Wang J, Gao N, George Fu Gao*, (2017) Alternate Binding Modes of Anti-CRISPR Viral Suppressors AcrF1/F2 to Csy Surveillence Complex Revealed by Cryo-EM structures. Cell Res., 27, 853-864.
6. Song H, Qi J, Xiao H, Bi Y, Zhang W, Xu Y, Wang F, Shi Y and George F. Gao. (2017) Avian-to-Human Receptor-Binding Adaptation by Influenza A Virus Hemagglutinin H4. Cell Rep., 20, 1201-1214.
7. Ge H, Xu P, Xu Y, Fang Z, Xiao Y. (2011) Purification, Crystallization and Preliminary Crystallographic Analysis of Recombinant Lac15 from a Marine Microbial. Acta. Crystallogr. F., 67, 956-958.
